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ID 112032
タイトル別表記
画像強調内視鏡を用いたaberrant crypt fociの観察
著者
影本, 開三 徳島大学大学院医科学教育部(医学専攻)
Takaoka, Toshi Tokushima University
キーワード
ACF
NBI
BLI
IEE
Colorectal cancer
資料タイプ
学位論文
抄録
Background and study aims Conventional detection of aberrant crypt foci (ACF) with dye-spraying and magnifying observation is labor- and skill-intensive. We performed a prospective non-inferiority study to investigate the utility of image-enhanced endoscopy (IEE) for detection of ACF.
Patients and methods Patients with a history of colorectal neoplasm were eligible. The number of ACF in the lower rectum was counted first using IEE magnification with narrow- band imaging (NBI) or blue-laser imaging (BLI), and subsequently using the methylene blue method. The primary endpoint was the ACF detection rate with IEE, i. e., the number of ACF detected with IEE relative to the number of ACF detected with methylene blue. The secondary endpoints were bowel preparation time, ACF detection time, and the detection rate with NBI or BLI.
Results A total of 40 patients were enrolled (NBI 20 and BLI 20). The overall detection rate for ACF with IEE was 81.7% (503/616; 95%CI 78.8 – 84.6%), meeting the primary endpoint. The detection rate for ACF with BLI (84.9 %, 258/304) was significantly higher than with NBI (78.5%, 245/312; P < 0.05). Both bowel preparation time and ACF detection time were significantly shorter with IEE versus the methylene blue method (P < 0.01, respectively). The detection rates for dysplastic and non-dysplastic ACF with IEE were 84.4% (27/32) and 80.3% (469/584), respectively.
Conclusion IEE is able to detect ACF during colonoscopy with sensitivity non-inferior to that of the conventional methylene blue method. IEE is simpler than the methylene blue method and is therefore a potentially useful new tool for ACF detection.
掲載誌名
Endoscopy International Open
ISSN
21969736
出版者
Georg Thieme Verlag KG Stuttgart
6
8
開始ページ
E924
終了ページ
E933
発行日
2018-08-01
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Kaizo Kagemotoの学位論文として提出され, 学位審査・授与の対象となっている。
権利情報
©2018 Georg Thieme Verlag KG Stuttgart · New York
This article under License of Creative Commons Attribution 4.0 License. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ )
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3203号
学位記番号
甲医第1378号
学位授与年月日
2018-07-26
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系