てんかん患者の聴覚性誘発電位(AEP)および体性感覚誘発電位(SEP)

152 epileptics (male: 92, female: 60) and 200 normal subjects (100 of each sexes) were compared on AEP (Auditory Evoked Potential) and SEP (Somatosensory Evoked Potential), which were recorded through monopolar and bipolar derivations. The latencies and interpeak amplitudes of AEPs and VEPs were tested statistically by ANCOV A excluding the influence of age and drugs had been administered. The following results were obtained.

1. In AEPs, the latencies in epileptics were significantly longer compared with healthy subjects. These tendencies were more marked in short and middle latency components in males, but more marked in late components in females.
2. Interpeak amplitudes of AEP were relatively smaller in epileptics compared with healthy subjects.
3. In SEPs, the latencies were significantly longer in epileptics compared with healthy subjects. These tendencies were more marked in females.
4. There was no consistent tendency in interpeak amplitudes of SEP between epileptics and normal subjects in both sexes, but the interpeak amplitudes between predominant components were smaller in epileptics than normal subjects.
5. In epileptics, between the subjects had been administered the drug (each of CBZ, PB, VPA or PHT) or not, significant differences in latencies and interpeak amplitudes were not confirmed with the components significantly different in latencies and amplitudes between epileptics and healthy subjects were found.

We verified the significant differences in AEP and SEP between epileptics and healthy subjects excluding the influences of age and drugs, even not considering the seizure types nor epileptic focus sites. It was supposed the disturbance in auditory and somatosensory pathway up to cortex in the central nervous system in epileptics.