ID 112143
タイトル別表記
高Lp(a)血症におけるaspirinの効果
Effect of aspirin treatment on serum levels of lipoprotein (a) : analysis from the apolipoprotein (a) isoforms
著者
東, 博之 徳島大学
香川, 礼香 徳島大学
金川, 泰彦 徳島大学
松山, まどか 徳島大学
井内, 貴彦 徳島大学
高森, 信行 徳島大学
吉田, 智則 徳島大学
松本, 和也 国立療養所徳島病院
林, 郁郎 徳島県立中央病院
田村, 克也 健康保険鳴門病院
西内, 健 川島循環器クリニック
キーワード
lipoprotein (a)
apolipoprotein (a)
aspirin
apo(a) isoform
Lp(a) phenotype
資料タイプ
学術雑誌論文
抄録
We have found that aspirin lowers elevated serum lipoprotein(a) [Lp(a)] levels via reduction of the transcriptional activity of apolipoprotein(a) [apo(a)] gene with suppression of apo(a) mRNA expression. In the present study, we evaluated the effect of aspirin treatment on serum Lp(a) level and analyzed its relation to type of apo(a) isoform. Serum levels of Lp(a) were measured by turbidimetric immunoassay before and after the oral administration of aspirin therapy (81 mg/day) in 57 patients with coronary artery disease or cerebral infarction. Apo(a) isoforms were determined by immunoblotting method. In patients with high serum Lp(a) levels (more than 30 mg/dl), aspirin reduced serum Lp(a) levels to approximately 80 % of the baseline after one month. Their levels sustained significantly low even after six months. The effect of aspirin in reducing elevated serum Lp(a) levels were stronger in patients with smaller-sized type or double-band type of apo(a) isoforms. The transcriptional efficiency of apo(a) gene is thought to be increased in patients with these apo(a) isoforms. Therefore, these findings suggest that aspirin reduces apo(a) gene transcription preferentialy in patients with high transcriptional efficiency of this gene.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
55
3
開始ページ
109
終了ページ
114
並び順
109
発行日
1999-06-25
EDB ID
136183
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系
先端酵素学研究所