ID 112148
タイトル別表記
Pharmacotherapy and pathophysiology of schizophrenia
著者
キーワード
schizophrenia
antipsychotics
relapse
negative symptoms
amphetamine
資料タイプ
学術雑誌論文
抄録
Antipsychotic drugs are indispensable in the treatment of schizophrenia. They are useful in ameliorating positive symptoms as well as preventing psychotic relapses. However, there are patients who become refractory to the drug after repeated relapses. We conducted a retrospective study in fifty outpatients with paranoid schizophrenia who have been seen at our clinic for a duration of 15 years or more since their first psychotic episodes. It was found that the maintenance dose was correlated significantly with the number of previous relapses and total duration of psychotic episodes. These results suggest that repetitive psychotic relapses lead to a lower threshold for relapse and consequently require a higher antipsychotic dose for prevention. Behavioral sensitization to amphetamine may provide a model to study neuroplastic change after repeated relapses.
Another limitation of antipsychotic drugs is the lack of effects in the negative symptoms. A dopamine agonist rather than a dopamine antagonist may be useful in the treatment of negative symptoms. Atypical antipsychotics may have some advantage to improve these symptoms. In addition to the dopaminergic system, glutamatergic and serotonergic systems seem to be involved in the pathophysiology of the negative symptoms of schizophrenia.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
55
4
開始ページ
143
終了ページ
147
並び順
143
発行日
1999-08-25
備考
p.143の図について、正誤表あり。(sam_55_4_143_2.PDF)
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系