ID 112274
タイトル別表記
Paraaortic lymph node recurrence in lung SCC
著者
Taniguchi, Haruki Urasoe General Hospital
Ishimine, Tomonari Urasoe General Hospital
Nakamura, Kei Urasoe General Hospital
Ishigaki, Masanobu Urasoe General Hospital
Fukumoto, Taizo Urasoe General Hospital
キーワード
lung squamous cell carcinoma
solitary paraaortic lymph node recurrence
資料タイプ
学術雑誌論文
抄録
Solitary abdominal paraaortic lymph node recurrence after radical lung cancer surgery is very rare. Here, we report a case of a solitary abdominal paraaortic lymph node recurrence of lung squamous cell carcinoma (SCC). A 63-year-old man was diagnosed with lung SCC (cT1cN0M0 stage IA3), underwent a video-assisted right lower lobectomy (ND2a-1), and the pathological findings showed SCC (pT1cN0M0 stage IA3). The EGFR mutation and ALK translocation statuses of SCC were negative, and adjuvant therapy was not performed. Follow-up positron emission tomography − computed tomography (PET/CT) showed a solitary fluorodeoxyglucose (FDG)- concentrated region in the swollen paraaortic lymph node. A paraaortic lymph node biopsy was performed by open laparotomy, to determine the precise diagnosis and identify the genetic status. Pathological findings revealed that the paraaortic lymph node contained poorly differentiated SCC, which was thought to metastasize from the lung cancer. The genetic status of the lymph node recurrence revealed a lack of EGFR mutations, ALK translocations, and ROS1 mutations, while the tumor proportion score (TPS) of PD-L1 was 55%, and we therefore administered pembrolizumab, an immune checkpoint inhibitor. Biopsies are very important for achieving precise diagnoses and determining the genetic statuses of tumors, since molecular-targeting drugs and immune checkpoint inhibitors are available.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA12022913
AA11166929
出版者
Faculty of Medicine Tokushima University
65
3-4
開始ページ
283
終了ページ
285
並び順
283
発行日
2018-08
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系