ID | 112441 |
著者 |
Gamrekelashvili, Jaba
Hannover Medical School
Giagnorio, Roberto
Hannover Medical School
Jussofie, Jasmin
Hannover Medical School
Soehnlein, Oliver
Ludwig-Maximilians-University|Amsterdam University|German Centre for Cardiovascular Research
Duchene, Johan
Ludwig-Maximilians-University
Briseño, Carlos G.
Washington University in St Louis
Ramasamy, Saravana K.
Max Planck Institute for Molecular Biomedicine
Krishnasamy, Kashyap
Hannover Medical School
Limbourg, Anne
Hannover Medical School
Häger, Christine
Hannover Medical School
Kapanadze, Tamar
Hannover Medical School
Hinkel, Rabea
Ludwig-Maximilians-University|Technical University of Munich
Radtke, Freddy
Ecole Polytechnique Fédérale de Lausanne
Strobl, Lothar J.
German Research Center for Environment and Health (GmbH)
Zimber-Strobl, Ursula
German Research Center for Environment and Health (GmbH)
Napp, L. Christian
Hannover Medical School
Bauersachs, Johann
Hannover Medical School
Haller, Hermann
Hannover Medical School
Kupatt, Christian
Ludwig-Maximilians-University|Technical University of Munich
Murphy, Kenneth M.
Washington University in St Louis
Adams, Ralf H.
Max Planck Institute for Molecular Biomedicine
Weber, Christian
Ludwig-Maximilians-University|Cardiovascular Research Institute Maastricht (CARIM)
Limbourg, Florian P.
Hannover Medical School
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資料タイプ |
学術雑誌論文
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抄録 | A population of monocytes, known as Ly6Clo monocytes, patrol blood vessels by crawling along the vascular endothelium. Here we show that endothelial cells control their origin through Notch signalling. Using combinations of conditional genetic deletion strategies and cell-fate tracking experiments we show that Notch2 regulates conversion of Ly6Chi monocytes into Ly6Clo monocytes in vivo and in vitro, thereby regulating monocyte cell fate under steady-state conditions. This process is controlled by Notch ligand delta-like 1 (Dll1) expressed by a population of endothelial cells that constitute distinct vascular niches in the bone marrow and spleen in vivo, while culture on recombinant DLL1 induces monocyte conversion in vitro. Thus, blood vessels regulate monocyte conversion, a form of committed myeloid cell fate regulation.
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掲載誌名 |
Nature Communications
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ISSN | 20411723
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cat書誌ID | AA12645905
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出版者 | Springer Nature
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巻 | 7
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開始ページ | 12597
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発行日 | 2016-08-31
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備考 | Supplementary Information : ncomms_7_12597_s1.pdf
Corrigendum : https://doi.org/10.1038/ncomms15486 |
権利情報 | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
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出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
医学系
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