アクセス数 : ?
ダウンロード数 : ?
ID 112503
タイトル別表記
β-Carotene Suppresses Cytokine Production
著者
Lew, Jung Hwan Tokushima University
キーワード
β‐carotene
diabetic complications
glucose
monocyte
Porphyromonas gingivalis LPS
資料タイプ
学術雑誌論文
抄録
Periodontitis is associated with development of diabetes mellitus. Although lipopolysaccharide (LPS) of Porphyromonas gingivalis (Pg), a major pathogen of periodontitis, may lead the progression of diabetes complications, the precise mechanisms are unclear. We, therefore, investigated the effects of β-carotene on production of Pg LPS-induced inflammatory cytokines in human monocytes cultured high glucose (HG) condition. THP-1 cells were cultured under 5.5 mM or 25 mM glucose conditions, and cells were stimulated with Pg LPS. To investigate the productivity of TNF-α, IL-6 and MCP-1, cell supernatants were collected for ELISA. To examine the effects of NF-kB signals on cytokine production, Bay11-7082 was used. HG enhanced Pg LPS-induced production of TNF-α, IL-6 and MCP-1 via NF-kB signals in THP-1. β-carotene suppressed the enhancement of the Pg LPS-induced cytokine production in THP-1 via NF-κB inactivation. Our results suggest that β-carotene might be a potential anti-inflammatory nutrient for circulating Pg LPS-mediated cytokine production in diabetic patients with periodontitis.
掲載誌名
Cell Biology International
ISSN
10958355
cat書誌ID
AA11544414
AA10882014
出版者
International Federation for Cell Biology|Wiley
42
1
開始ページ
105
終了ページ
111
発行日
2017-10-25
備考
This is the peer reviewed version of the following article: Kajiura, Y. , Nishikawa, Y. , Lew, J. H., Kido, J. , Nagata, T. and Naruishi, K. (2018), β‐carotene suppresses Porphyromonas gingivalis lipopolysaccharide‐mediated cytokine production in THP‐1 monocytes cultured with high glucose condition. Cell Biol Int, 42: 105-111, which has been published in final form at https://doi.org/10.1002/cbin.10873. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
歯学系
病院