ID | 112874 |
タイトル別表記 | AUC of insulin secretion in diabetes
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著者 |
Ebe, Koji
Japan Low Carbohydrate Diet Promotion Association|Takao Hospital
Muneta, Tetsuo
Japan Low Carbohydrate Diet Promotion Association|Muneta Maternity Clinic
板東, 正浩
Tokushima University
Yonei, Yoshikazu
Doshisha University
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キーワード | Area Under the Curves (AUC)
Insulinogenic index (IGI)
type 2 diabetes mellitus (T2DM)
Morbus value (M value)
Delta ratio of IGI
AUC ratio of IGI
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資料タイプ |
学術雑誌論文
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抄録 | Background
Concerning diabetic nutritional therapy, Calorie Restriction (CR) and Low Carbohydrate Diet (LCD) have been on discussion. Authors continue clinical research related to CR, LCD, Morbus(M) value and insulin secretion. Subjects and Methods Subjects were 42 patients (63.4 years on average) with type 2 diabetes mellitus (T2DM) with its immunoreactive insulin (IRI) =<5μU/mL. Methods included CR breakfast with carbohydrate 70g (Carbo70), Insulinogenic Index (IGI) calculation and daily profile of blood glucose. Results Subjects showed median data; M value 207, HOMA-R 1.0, Delta Ratio of IGI for Carbo70 is 0.12 [0.08–0.22], Area under the Curves (AUC) Ratio of IGI-Carbo70 is 3.0 [2.2-4.8]. Divided into 3 groups due to HbA1c, median glucose and M value was 133mg/dL, 227 mg/dL, 345mg/dL and 15.8, 207, 587, respectively. Delta and AUC Ratio of IGI-Carbo70 in 3 groups were 0.17, 0.10, 0.10and5.2, 2.9, 1.9, respectively. There were significant correlations between M value and Delta ratio / AUC ratio, in which the latter has higher degree of significance. Discussion and Conclusion Among 3 groups, the distribution was overlapped in Delta-IGI, and was rather divided in AUC-IGI. Consequently, the latter method seems to be rather superior. These results would be the fundamental data, and further development of research is expected. |
掲載誌名 |
International Journal of Biotechnology and Recent Advances
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ISSN | 26394529
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出版者 | Madridge Publishers
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巻 | 1
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号 | 1
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開始ページ | 24
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終了ページ | 29
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発行日 | 2018-07-19
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権利情報 | © 2018 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
医学系
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