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ID 112881
タイトル別表記
生殖補助医療を行っている患者において卵胞液中のキスペプチン濃度は卵成熟および性腺ホルモン値と関連している
著者
谷口, 友香 徳島大学大学院医科学教育部(医学専攻)
Tachibana, Ayaka The University of Tokushima
Yano, Yuya The University of Tokushima
矢野, 清人 The University of Tokushima
山﨑, 幹雄 The University of Tokushima KAKEN研究者をさがす
檜尾, 健二 The University of Tokushima
松崎, 利也 The University of Tokushima KAKEN研究者をさがす
キーワード
Assisted reproductive technology
estradiol
follicular fluid
kisspeptin
mature oocyte
資料タイプ
学位論文
抄録
Purpose: To assess the kisspeptin concentrations in follicular fluid and their relationship with clinical outcomes during assisted reproductive technology.
Methods: Thirty-nine patients who were aged 24-40 years and underwent oocyte retrieval for in vitro fertilization/intracytoplasmic sperm injection participated in this study. In 65 follicular fluid samples that had been obtained from 30 patients and their blood samples, the kisspeptin levels were measured in order to investigate the correlations with their gonadal hormone levels. Venous blood samples were collected from 14 patients to investigate their plasma kisspeptin levels across different phases of assisted reproductive technology.
Results: The follicular fluid kisspeptin level was significantly higher than that of the plasma level and was positively associated with the follicular fluid estradiol concentration and with the serum estradiol and number of mature oocytes. In the plasma, the maximum concentration of kisspeptin was observed on the day of ovum pick-up and on the day of embryo transfer during ovarian stimulation for assisted reproductive technology.
Conclusion: Kisspeptin was present in the follicular fluid and the plasma kisspeptin concentration was affected by ovarian stimulation. Kisspeptin appears to affect oocyte maturation and ovulation.
掲載誌名
Reproductive Medicine and Biology
ISSN
14470578
cat書誌ID
AA11706516
出版者
Wiley|Japan Society for Reproductive Medicine
16
4
開始ページ
380
終了ページ
385
発行日
2018-09-16
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Yuka Taniguchiの学位論文として提出され, 学位審査・授与の対象となっている。
権利情報
Copyright © 2017 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine.
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3219号
学位記番号
甲医第1387号
学位授与年月日
2018-09-27
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系