ID 113060
著者
Kusaka, Ryo Tokushima University
キーワード
Ritter reaction
Bismuth
Lewis acids
Organic solvent free process
Catalyst
資料タイプ
学術雑誌論文
抄録
We developed an environmentally benign Ritter reaction of alcohols with nitriles using a commercially available bismuth salt as a less harmful catalyst. The detailed reaction profiles revealed that consumption of the ether by-product as the reaction proceeded was the key for optimizing this reaction, and the yield of the target amide was improved by adding a small amount of water. This finding clearly reveals the significance of using a bismuth salt as the catalyst, as it is not deactivated in the presence of water. This catalyst system has a broad substrate scope, and even with 1 mol% of the catalyst, the reaction progresses smoothly. It is also possible to react stoichiometric amounts of nitriles and alcohols, thus reducing the amount of organic solvent required for the reaction. Furthermore, as the inexpensive bismuth catalyst can be easily removed using aqueous hydrochloric acid, a purification process that only required washing and drying without any organic solvents was successfully established.
掲載誌名
European Journal of Organic Chemistry
ISSN
1434193X
10990690
cat書誌ID
AA1118165X
AA11619885
出版者
WILEY‐VCH
2019
8
開始ページ
1796
終了ページ
1800
発行日
2019-01-09
備考
This is the pre-peer reviewed version of the following article: Ueno, M. , Kusaka, R. , Ohmura, S. D. and Miyoshi, N. (2019), Environmentally Benign Ritter Reaction Using Bismuth Salts as a Catalyst. Eur. J. Org. Chem., 2019: 1796-1800, which has been published in final form at https://doi.org/10.1002/ejoc.201801882. This article may be used for non-commercial purposes in accordance with Wiley-VCH Terms and Conditions for Self-Archiving.
Accepted versionは2020-02-03以降公開予定
EDB ID
349610
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
理工学系