ID | 113324 |
タイトル別表記 | 子宮内膜症モデルマウスにおいてLPSは腹膜子宮内膜症初期病巣形成を促進する
LPS proliferate the endometriosis
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著者 |
門田, 友里
Tokushima University
Erdenebayar, Otgontsetseg
Tokushima University
Kasai, Kana
Tokushima University
谷, 杏奈
Iseikai Hospital
Maegawa, Masahiko
Tokushima Prefectural Central Hospital
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キーワード | LPS
endometriosis
inflammation
Murine model
cytokine
mice model
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資料タイプ |
学位論文
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抄録 | Purpose : The aims of this study were to clarify the effects of lipopolysaccharide (LPS) on the early development of endometriosis and on the production of cytokines and chemokines in the murine peritoneal cavity. Methods : Endometriotic lesions were induced in C57BL/6J adult female mice by intraperitoneal injection of endometrial fragments plus blood or endometrial fragments plus blood with LPS. On day 7, endometriotic lesions were assessed by gross and microscopic evaluations. Time-dependent changes in the secretion of TNF-α, IL-6, and CXCL2/MIP-2 in peritoneal lavage fluid after the intraperitoneal injection of LPS (50 µg/body) were measured by their respective enzyme-linked immunosorbent assays. Results : The areas of endometriotic lesions in the LPS group (10.8±8.6 mm2) were significantly larger than those in the control group (3.1±3.7 mm2). The levels of TNF-α and IL-6 peaked within 2 hours and the level of MIP-2 reached a maximum on day 1 after the injection of LPS. Conclusions : LPS promotes development of the early stages of murine endometriotic lesions.
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掲載誌名 |
The Journal of Medical Investigation
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ISSN | 13496867
13431420
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cat書誌ID | AA12022913
AA11166929
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出版者 | Tokushima University Faculty of Medicine
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巻 | 66
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号 | 1-2
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開始ページ | 70
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終了ページ | 74
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並び順 | 70
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発行日 | 2019-02
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備考 | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Kaoru Keyamaの学位論文として提出され,学位審査・授与の対象となっている。 |
EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
博士論文全文を含む
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文科省報告番号 | 甲第3248号
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学位記番号 | 甲医第1397号
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学位授与年月日 | 2018-12-27
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学位名 |
博士(医学)
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学位授与機関 |
徳島大学
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部局 |
病院
医学系
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