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ID 113365
タイトル別表記
Senescence-accelerated mouse-prone 8 (SAMP8)マウスにおけるオリーブオイル摂取の老化への効果
Effects of olive oil in SAMP8 mice
著者
板東, 正浩 徳島大学大学院栄養生命科学教育部(人間栄養科学専攻)
升本, 早枝子 Tokushima University
キーワード
Mediterranean diet
olive oil
MUFA
SAMP8
aging
passive avoidance
資料タイプ
学位論文
抄録
Background : Mediterranean diets have been linked to a reduced risk of cancer, vascular illnesses, Parkinson’s and Alzheimer’s disease. Olive oil is the primary fat source in the Mediterranean diet ; however, only a few studies have investigated the effect of olive oil on aging. In the present study, we aimed to determine whether consumption of olive oil significantly influences aging and memory in senescence-accelerated mouse-prone 8 (SAMP8). Methods : SAMP8 and senescence-accelerated mouse resistant 1 (SAMR1) mice were fed either 7% soy oil or 1% olive oil and 6% soy oil during a six-month study period. Reduction in memory in passive avoidance learning was examined after two months from the initiation of the experiment. Results : The weight of organs including the liver, kidney, spleen, and fat tissue changed significantly and memory performance was reduced in SAMP8 than in SAMR1 mice. There were no significant differences in SAMP8 and SAMR1 mice; however, blood triglyceride level decreased significantly in SAMP8 mice fed on olive oil. Conclusions : These results suggest that consuming olive oil may not have a protective role in aging and memory recall, but beneficial effects may be related to improvement in lipid metabolism.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA12022913
AA11166929
出版者
Tokushima University Faculty of Medicine
66
3-4
開始ページ
241
終了ページ
247
並び順
241
発行日
2019-08
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Masahiro Bandoの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3276号
学位記番号
甲栄第265号
学位授与年月日
2019-03-22
学位名
博士(栄養学)
学位授与機関
徳島大学
部局
医学系