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ID 113639
著者
Ogura, Yuki Tokushima University
Atsuta, Kosuke Tokushima University
キーワード
Optical microscopy
Optical harmonic generation
Biophotonics
Biomedical optical imaging
資料タイプ
学術雑誌論文
抄録
Second-harmonic-generation (SHG) microscopy is a powerful tool for in vivo monitoring of collagen fibers in human skin. Furthermore, polarization-resolved SHG microscopy can provide additional insights regarding the direction of collagen fibers, i.e., collagen fiber orientation. However, their practical use in the dermatological field is still limited due to the bulky and complicated setup. In this paper, we constructed a photonic-crystal-fiber-coupled, hand-held polarization-resolved SHG microscope for in vivo monitoring of collagen fibers in human skin. Fiber delivery of ultrashort pulse light was achieved without significant change of the linear polarization by a large-mode-area photonic-crystal-fiber whereas the SHG microscopy setup was enclosed into a hand-held probe head. The combination of PCF with the hand-held probe head largely enhances the flexibility of measurement sites in the human skin.
掲載誌名
IEEE Journal of Selected Topics in Quantum Electronics
ISSN
1077260X
15584542
cat書誌ID
AA11036333
出版者
IEEE
25
1
開始ページ
6801007
発行日
2018-08-17
権利情報
© 2018 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
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出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
理工学系