ID | 113791 |
タイトル別表記 | 腎臓の発達過程である新生児においてアンジオテンシノーゲンの発現は増強している
Angiotensinogen expression in neonates
|
著者 |
庄野, 実希
徳島大学大学院医科学教育部(医学専攻)
Watanabe, Noriko
Tokushima University
|
キーワード | Angiotensinogen
renin-angiotensin system
kidney development
neonates
|
資料タイプ |
学位論文
|
抄録 | Background
We recently demonstrated that preterm neonates have higher urinary angiotensinogen (AGT) levels than full-term neonates. Here, we tested the hypothesis that enhanced neonatal AGT expression is associated with intrarenal renin-angiotensin system (RAS) status during kidney development. Methods We prospectively recruited neonates born at our hospital and healthy children with minor glomerular abnormalities between April 2013 and March 2017. We measured neonatal plasma and urinary AGT levels at birth and one year later and assessed renal AGT expression in kidney tissues from neonates and healthy children using immunohistochemical (IHC) analysis. Results Fifty-four neonates and eight children were enrolled. Although there were no changes in plasma AGT levels, urinary AGT levels were significantly decreased one year after birth. Urinary AGT levels at birth were inversely correlated with gestational age, and urinary AGT levels at birth and one year later were inversely correlated with estimated glomerular filtration rate one year after birth. IHC analysis showed that renal AGT expression in neonates was higher than that in healthy children and inversely correlated with gestational age. Conclusions Enhanced AGT expression and urinary AGT excretion may reflect intrarenal RAS activation associated with kidney development in utero. |
掲載誌名 |
Clinical and Experimental Nephrology
|
ISSN | 13421751
14377799
|
cat書誌ID | AA11126935
|
出版者 | Springer Singapore|Japanese Society of Nephrology
|
巻 | 23
|
号 | 4
|
開始ページ | 537
|
終了ページ | 543
|
発行日 | 2018-10-23
|
備考 | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Miki Shonoの学位論文として提出され,学位審査・授与の対象となっている。 This is a post-peer-review, pre-copyedit version of an article published in Clinical and Experimental Nephrology. The final authenticated version is available online at: https://doi.org/10.1007/s10157-018-1662-3 |
権利情報 | © Japanese Society of Nephrology 2018
|
EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
|
著者版フラグ |
博士論文全文を含む
|
文科省報告番号 | 甲第3334号
|
学位記番号 | 甲医第1428号
|
学位授与年月日 | 2019-09-26
|
学位名 |
博士(医学)
|
学位授与機関 |
徳島大学
|
部局 |
病院
医学系
|