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ID 113942
著者
Matsumoto, Tomoya Tokushima University
Toguchi, Munehisa Tokushima University
キーワード
Horner-Wadsworth-Emmons reagents
Still-Gennari reagent
phosphorus
Garegg-Samuelsson reaction conditions
2,2,2-trifluoroethanol
資料タイプ
学術雑誌論文
抄録
A facile two-step synthesis of methyl bis(2,2,2-trifluoroethyl)phosphonoacetate (Still–Gennari reagent) has been developed by exploiting Garegg–Samuelsson reaction conditions. Starting from trimethyl phosphonoacetate, Still–Gennari reagent was prepared in 94% yield via methyl 2-{bis[(trimethylsilyl)oxy]phosphoryl}acetate intermediate. This synthetic procedure was also used to prepare some kinds of Horner–Wadsworth–Emmons reagents and related compounds.
掲載誌名
Synlett
ISSN
09365214
14372096
cat書誌ID
AA10731110
出版者
Georg Thieme Verlag Stuttgart
29
11
開始ページ
1461
終了ページ
1464
発行日
2018-04-13
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
薬学系