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ID 113948
著者
Ono, Akemi Tokushima University
キーワード
Tissue Doppler imaging
Pulmonary annular motion
Pulmonary arterial compliance
Children
資料タイプ
学術雑誌論文
抄録
Background: We hypothesized that longitudinal pulmonary arterial deformation during the cardiac cycle reflects pulmonary arterial capacitance. To examine this hypothesis, we assessed whether tissue Doppler-derived pulmonary annular motion could serve as a novel way to evaluate pulmonary arterial capacitance in pediatric patients with ventricular septal defect (VSD).
Methods: In this prospective study, pulmonary annular velocity was measured in children (age, 6 months–5 years) with a preoperative VSD (VSD group, n = 35) and age-matched healthy children (Control group, n = 23). Pulmonary artery capacitance was calculated by two methods. Systolic pulmonary arterial capacitance (sPAC) was expressed as the stroke volume/pulmonary arterial pulse pressure. Diastolic pulmonary arterial capacitance (dPAC) was determined according to a two-element windkessel model of the pulmonary arterial diastolic pressure profile.
Results: Pulmonary annular velocity waveforms comprised systolic bimodal (s1′ and s2′) and diastolic e’ and a’ waves in all participants. The peak velocities of s1′, s2′, and e’ were significantly lower in the VSD group than in the Control group. On multiple regression analysis, sPAC was an independent variable affecting the peak velocities of the s1′, s2′, and e’ waves (β = 0.41, 0.62, and 0.35, respectively). The dPAC affected the s1′ wave peak velocity (β = 0. 34). The time durations of the s1′ and e’ waves were independently determined by the sPAC (β = 0.49 and 0.27).
Conclusion: Pulmonary annular motion velocity evaluated using tissue Doppler is a promising method of assessing pulmonary arterial capacitance in children with VSD.
掲載誌名
Cardiovascular Ultrasound
ISSN
14767120
出版者
BioMed Central|Springer Nature
14
開始ページ
38
発行日
2016-09-07
権利情報
© 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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cu_14_38.pdf 1.64 MB
言語
eng
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部局
医学系