ID | 113989 |
著者 |
Goto, Daichi
Osaka University
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キーワード | Low-magnitude vibration
Cortical bone defect
Vascular ingrowth
Synchrotron radiation
K-edge subtraction
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資料タイプ |
学術雑誌論文
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抄録 | Low-intensity whole-body vibration (LIWBV) may stimulate bone healing, but the involvement of vascular ingrowth, which is essential for bone regeneration, has not been well examined. We thus investigated the LIWBV effect on vascularization during early-stage bone healing. Mice aged 13 weeks were subjected to cortical drilling on tibial bone. Two days after surgery (day 0), mice were exposed daily to sine-wave LIWBV at 30 Hz and 0.1 g peak-to-peak acceleration for 20 min/day (Vib) or were sham-treated (sham). Following vascular casting with a zirconium-based contrast agent on days 6, 9, or 12 and sacrifice, vascular and bone images were obtained by K-edge subtraction micro-CT using synchrotron lights. Bone regeneration advanced more in the Vib group from days 9 to 12. The vascular volume fraction decreased from days 6 to 9 in both groups; however, from days 9 to 12, it was increased in shams, while it stabilized in the Vib group. The vascular volume fraction tended to be or was smaller in the Vib group on days 6 and 12. The vessel number density was higher on day 9 but lower on day 12 in the Vib group. These results suggest that the LIWBV-promoted bone repair is associated with the modulation of vascularization, but additional studies are needed to determine the causality of this association.
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掲載誌名 |
Medical & Biological Engineering & Computing
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ISSN | 01400118
17410444
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cat書誌ID | AA00726781
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出版者 | Springer Berlin Heidelberg
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巻 | 55
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号 | 12
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開始ページ | 2257
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終了ページ | 2266
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発行日 | 2017-06-29
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備考 | This is a post-peer-review, pre-copyedit version of an article published in Medical & Biological Engineering & Computing. The final authenticated version is available online at: https://doi.org/10.1007/s11517-017-1664-4.
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言語 |
eng
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著者版フラグ |
著者版
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部局 |
理工学系
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