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ID 113989
著者
Goto, Daichi Osaka University
キーワード
Low-magnitude vibration
Cortical bone defect
Vascular ingrowth
Synchrotron radiation
K-edge subtraction
資料タイプ
学術雑誌論文
抄録
Low-intensity whole-body vibration (LIWBV) may stimulate bone healing, but the involvement of vascular ingrowth, which is essential for bone regeneration, has not been well examined. We thus investigated the LIWBV effect on vascularization during early-stage bone healing. Mice aged 13 weeks were subjected to cortical drilling on tibial bone. Two days after surgery (day 0), mice were exposed daily to sine-wave LIWBV at 30 Hz and 0.1 g peak-to-peak acceleration for 20 min/day (Vib) or were sham-treated (sham). Following vascular casting with a zirconium-based contrast agent on days 6, 9, or 12 and sacrifice, vascular and bone images were obtained by K-edge subtraction micro-CT using synchrotron lights. Bone regeneration advanced more in the Vib group from days 9 to 12. The vascular volume fraction decreased from days 6 to 9 in both groups; however, from days 9 to 12, it was increased in shams, while it stabilized in the Vib group. The vascular volume fraction tended to be or was smaller in the Vib group on days 6 and 12. The vessel number density was higher on day 9 but lower on day 12 in the Vib group. These results suggest that the LIWBV-promoted bone repair is associated with the modulation of vascularization, but additional studies are needed to determine the causality of this association.
掲載誌名
Medical & Biological Engineering & Computing
ISSN
01400118
17410444
cat書誌ID
AA00726781
出版者
Springer Berlin Heidelberg
55
12
開始ページ
2257
終了ページ
2266
発行日
2017-06-29
備考
This is a post-peer-review, pre-copyedit version of an article published in Medical & Biological Engineering & Computing. The final authenticated version is available online at: https://doi.org/10.1007/s11517-017-1664-4.
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言語
eng
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部局
理工学系