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ID 114021
タイトル別表記
Sarcopenia and AGEs in type 1 diabetes
著者
Araki, Michiko Tokushima University
Suzuki, Reiko Tokushima University
Akehi, Yuko Tokushima University
キーワード
Advanced glycation end-products
Sarcopenia
Type 1 diabetes
資料タイプ
学術雑誌論文
抄録
Accumulation of advanced glycation end-products (AGEs) is thought to contribute to muscle weakness in a diabetic animal model. Skin autofluorescence is a proposed marker for accumulation of AGEs in the skin. We aimed to investigate the relationship between AGEs accumulation, sarcopenia and muscle function of Japanese patients with type 1 diabetes. A total of 36 patients with type 1 diabetes participated in the present cross-sectional study. Sarcopenia parameters (skeletal muscle mass index and knee extension strength) were compared with subcutaneous AGEs accumulation using skin autofluorescence. The prevalence of sarcopenia and impaired knee extension strength was 16.6% (men 0.0%, women 22.2%) and 47.2% (men 22.2%, women 55.6%), respectively. Knee extension strength was negatively correlated with skin autofluorescence (r² = 0.14, P < 0.05), but not with skeletal muscle mass index. In conclusion, the AGEs accumulation might be one of the reasons of impaired lower limb muscle function in Japanese patients with type 1 diabetes.
掲載誌名
Journal of Diabetes Investigation
ISSN
20401124
出版者
Asian Association for the Study of Diabetes|John Wiley & Sons Australia
8
3
開始ページ
377
終了ページ
382
発行日
2016-10-11
権利情報
© 2016 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License(https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
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言語
eng
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出版社版
部局
先端酵素学研究所