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ID 114023
タイトル別表記
Osteocalcin and body fat in type 1 diabetes
著者
髙士, 祐一 Tokushima University
Ishizu, Masashi Tokushima University
Miyashita, Kazuyuki Osaka University
Sakamoto, Fumie Osaka University
Katakami, Naoto Osaka University
Matsuoka, Taka-aki Osaka University
Yasuda, Tetsuyuki Osaka Police Hospital
橋田, 誠一 Tokushima Bunri University
資料タイプ
学術雑誌論文
抄録
The objective of the present study was to investigate the correlations between serum under-carboxylated osteocalcin (ucOC) or osteocalcin (OC) concentrations and %body fat, serum adiponectin and free-testosterone concentration, muscle strength and dose of exogenous insulin in patients with type 1 diabetes. We recruited 73 Japanese young adult patients with childhood-onset type 1 diabetes. All participants were receiving insulin replacement therapy. The correlations between logarithmic serum ucOC or OC concentrations and each parameter were examined. Serum ucOC and OC concentrations were inversely correlated with% body fat (r = -0.319, P = 0.007; r = -0.321, P = 0.006, respectively). Furthermore, multiple linear regression analyses were performed to determine whether or not serum ucOC or OC concentrations were factors associated with %body fat. Serum ucOC and OC concentrations remained significant factors even after adjusting for gender, HbA1c, body weight-adjusted total daily dose of insulin and duration of diabetes (β = -0.260, P = 0.027; β = -0.254, P = 0.031, respectively). However, serum ucOC and OC concentrations were not correlated with serum adiponectin or free-testosterone concentrations, muscle strength or dose of exogenous insulin. In conclusion, our study demonstrates the inverse correlation between serum ucOC or OC concentrations and body fat in patients with type 1 diabetes.
掲載誌名
PLOS ONE
ISSN
19326203
出版者
PLOS
14
5
開始ページ
e0216416
発行日
2019-05-03
権利情報
© 2019 Takashi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
先端酵素学研究所