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ID 114079
著者
Afroz, Shaista Aligarh Muslim University
Dalanon, Junhel C. Tokushima University
Waskitho, Arief Tokushima University
キーワード
Orofacial pain
Neuropathic pain
Sensory ganglia
Neurotransmitter
Glial cell
Cytokine
資料タイプ
学術雑誌論文
抄録
Neuropathic pain (NP) develops because of damage to the peripheral or central nervous system. It results in the hyperalgesia and allodynia. In the recent years, various researchers have studied the involvement of neuro-immune system in causing persistence of pain. The absence of synaptic contacts in the sensory ganglion makes them distinctive in terms of pain related signalling. In sensory ganglia, the neurotransmitters or the other modulators such as inflammatory substances produced by the ganglion cells, because of an injury, are responsible for the cross-excitation between neurons and neuron-glial interaction, thus affecting chemical transmission. This chemical transmission is considered mainly responsible for the chronicity and the persistent nature of neuropathic pain. This review examines the pain signalling due to neurotransmitter or cytokine release within the sensory ganglia. The specific areas focused on include: 1) the role of neurotransmitters released from the somata of sensory neurons in pain , 2) neuron-glia interaction and 3) role of cytokines in neuromodulation and pain.
掲載誌名
Neuroscience & Biobehavioral Reviews
ISSN
01497634
cat書誌ID
AA00324096
AA11540934
出版者
Elsevier
108
開始ページ
393
終了ページ
399
発行日
2019-11-27
権利情報
© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系