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ID 114098
タイトル別表記
Intrastriatal Memantine Infusion
著者
Ogawa, Masatoshi Tokushima University
Zhou, Yu Tokushima University
Tsuji, Ryosuke Tokushima University
キーワード
intracerebral brain infusion
levodopa-induced dyskinesia
memantine
N-methyl-D-aspartate receptor
Parkinson’s disease
資料タイプ
学術雑誌論文
抄録
Although the administration of dopamine precursor levodopa remains as the mainstay for the treatment of Parkinson’s disease, long-term exposure to levodopa often causes a disabling complication, referred to as levodopa-induced dyskinesias. Therefore, the development of new therapeutic interventions to dampen levodopa-induced dyskinesias and parkinsonian motor deficits is needed in the treatment of Parkinson’s disease. Intracerebral brain infusion has the merit of being able to specifically deliver any drug into any brain part. By using an intracerebral infusion system equipped with implantable, programmable, and refillable pumps, we show herein that continuous intrastriatal administration of memantine (MMT), which is a non-competitive N-methyl-D-aspartate receptor antagonist, attenuates levodopa-induced dyskinesias and parkinsonian signs in 6-hydroxydopamine-lesioned hemiparkinsonian mice that received daily levodopa treatment. Corroborating the general thought that overactivation of the striatal N-methyl-D-aspartate receptor function might generate levodopa-induced dyskinesias and parkinsonism, our results suggest that a continuous intrastriatal MMT infusion can be beneficial for the management of Parkinson’s disease with levodopa-induced dyskinesias. Our study also provides indications for the prototypic use of pharmacological deep-brain modulation through intracerebral infusion systems for treating medically intractable movement disorders.
掲載誌名
Frontiers in Neurology
ISSN
16642295
出版者
Frontiers
10
開始ページ
1258
発行日
2019-12-05
権利情報
© 2019 Ogawa, Zhou, Tsuji, Kasahara and Goto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)(https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
薬学系
医学系