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ID 114283
著者
Ueta, Shun Tokushima University
Okamoto, Takuma Tokushima University
キーワード
nitrone
flow
microreactor
nucleophilic addition
nitrogen-containing compound
資料タイプ
学術雑誌論文
抄録
Nucleophilic addition reactions of soft carbon nucleophiles to nitrones in a flow microreactor are reported for the first time. Under microflow conditions at 30 °C to 0 °C, a range of nitrones can be efficiently transformed into the corresponding oxyiminium ions by reacting with either acyl halides or trialkylsilyl triflates, which can subsequently undergo the addition of nucleophiles including allyltributylstannane, ketene methyl tert-butyldimethylsilyl acetal, and N-silyl ketene imines to afford the corresponding adducts in high yields, while such reactions at a similar temperature under batch conditions have resulted in lowering the yields due to undesired side reactions.
掲載誌名
Synlett
ISSN
09365214
14372096
cat書誌ID
AA10731110
出版者
Georg Thieme Verlag
31
9
開始ページ
866
終了ページ
870
発行日
2020-02-18
備考
論文本文は2021-02-18以降公開予定
EDB ID
出版社版DOI
出版社版URL
言語
eng
著者版フラグ
その他
部局
理工学系
教養教育院