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ID 114298
タイトル別表記
Dopaminergic Inhomogeneity of Human Putamen
著者
キーワード
putamen
matrix compartment
striosomes
tyrosine hydroxylase
human brain
immunohistochemistry
資料タイプ
学術雑誌論文
抄録
Among the basal ganglia-thalamocortical circuits, the putamen plays a critical role in the “motor” circuits that control voluntary movements and motor learning. The human neostriatum comprises two functional subdivisions known as the striosome (patch) and matrix compartments. Accumulating evidence suggests that compartment-specific dysregulations of dopamine activity might be involved in the disease-specific pathology and symptoms of human striatal diseases including movement disorders. This study was undertaken to examine whether or how striatal dopaminergic innervations are organized into the compartmentalized architecture found in the putamen of adult human brains. For this purpose, we used a highly sensitive immunohistochemistry (IHC) technique to identify tyrosine hydroxylase (TH; EC 1.14.16.2), a marker for striatal dopaminergic axons and terminals, in formalin-fixed paraffin-embedded (FFPE) tissues obtained from autopsied human brains. Herein, we report that discrete compartmentalization of TH-labeled innervations occurs in the putamen, as in the caudate nucleus (CN), with a higher density of TH labeling in the matrix compared to the striosomes. Our results provide anatomical evidence to support the hypothesis that compartment-specific dysfunction of the striosome-matrix dopaminergic systems might contribute to the genesis of movement disorders.
掲載誌名
Frontiers in Neuroanatomy
ISSN
16625129
出版者
Frontiers Media S.A.
10
開始ページ
34
発行日
2016-04-05
権利情報
© 2016 Morigaki and Goto. This is an open-access article distributed under the terms of the Creative Commons Attribution License(CCBY)( https://creativecommons.org/licenses/by/4.0/). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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言語
eng
著者版フラグ
出版社版
部局
医学系