直近一年間の累計
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ID 114358
タイトル別表記
Loss of Heterozygosity in Pheochromocytomas
著者
Yokogoshi, Yutaka The University of Tokushima
齋藤, 史郎 The University of Tokushima
キーワード
Pheochromocytoma
Loss of heterozygosity
Oncogene
Chromosome 11
資料タイプ
学術雑誌論文
抄録
Molecular genetic analysis was performed with 20 oncogene probes and 32 polymorphic DNA probes on tumor DNA samples from seven pheochromocytomas; namely, one multiple endocrine neoplasia type 2B, and two familial and four sporadic pheochromocytomas. No amplification or rearrangement of the oncogenes was detected in any of the tumors. However, loss of heterozygosity on chromosome 1p, 11p or 11q was detected in these cases. In addition, a locus related to ETS1 was deleted in two of the sporadic tumors. These results suggest that pheochromocytomas may be genetically heterogeneous, and that inactivation of unknown genes on chromosome 1p, 11p or 11q may contribute to their development.
掲載誌名
Japanese Journal of Cancer Research
cat書誌ID
AA00690844
出版者
Japanese Cancer Association|John Wiley & Sons
81
6-7
開始ページ
632
終了ページ
638
発行日
1990-06
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系