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ID 114392
著者
Ooguro, Yukari Tokushima University
森本, 佳奈 Tokushima University
キーワード
hypothalamic-pituitary-adrenal axis
adrenal insufficiency
chlormadinone acetate
prostate cancer
資料タイプ
学術雑誌論文
抄録
A 78-year-old Japanese man showed suppression of the hypothalamic-pituitary-adrenal axis during maximum androgen blockade (MAB) therapy including chlormadinone acetate (CMA) for prostate cancer. After stopping the MAB therapy, both the basal ACTH level and the response to CRH recovered. While no reports have indicated that CMA suppresses the hypothalamic-pituitary-adrenal axis in patients with prostate cancer, CMA has been shown to inhibit this axis in animals. These observations suggest that we must monitor the hypothalamic-pituitary-adrenal axis in patients treated with CMA, especially under stressful conditions.
掲載誌名
Internal Medicine
ISSN
13497235
出版者
The Japanese Society of Internal Medicine
55
24
開始ページ
3623
終了ページ
3626
発行日
2016-12-15
権利情報
The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系
先端酵素学研究所