直近一年間の累計
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ID 114494
タイトル別表記
Altered Gamma-Band Activity in Recovered Depression
著者
Sugaya, Nagisa Yokohama City University
Siegle, Greg J. University of Pittsburgh
Kumano, Hiroaki Waseda University
Shimada, Hironori Waseda University
Machado, Sergio Salgado de Oliveira University
Murillo-Rodriguez, Eric Universidad Anáhuac Mayab
Rocha, Nuno B. Polytechnic Institute of Porto
Nardi, Antonio E. Federal University of Rio de Janeiro
Takamura, Masahiro Hiroshima University
Okamoto, Yasumasa Hiroshima University
Yamawaki, Shigeto Hiroshima University
キーワード
cognitive reactivity
EEG
depression
gamma
mood induction
recovery
biomarker
memory
資料タイプ
学術雑誌論文
抄録
Background: The neurophysiological mechanisms of cognitive reactivity, the primary vulnerability factor of major depressive disorder (MDD) recurrence, remain unclear in individuals with recovered MDD (rMDD). Because gamma-band responses (GBRs) can be used to measure cognitive processing, they may also be useful for elucidating the mechanisms underlying cognitive reactivity. Identifying these mechanisms may permit the development of an index for predicting and preempting MDD recurrence. Here, to identify the neurophysiological mechanisms of cognitive reactivity, we examined the characteristics of the GBRs evoked/induced by emotional words in participants with and without rMDD after inducing a negative mood.
Methods: Thirty-three healthy control participants and 18 participants with rMDD completed a lexical emotion identification task during electroencephalography along with assessments of cognitive reactivity after negative mood induction.
Results: No between-group differences were identified for the task reaction times; however, the rMDD group had significantly higher cognitive reactivity scores than did the control group. Furthermore, the power of late GBRs to positive words was significantly greater in the rMDD group, with the greater power of late GBRs being related to higher cognitive reactivity.
Limitations: Considering the population studied, our findings cannot be completely generalized to populations other than adolescents, people with rMDD, and those without a history of co-morbid disorders and early life stress.
Conclusions: Our findings indicate that the dysfunction of neural circuits related to higher-order processes like memory and attention might underlie cognitive reactivity. Altered late GBRs to positive information may be persistent biomarkers of the depression recurrence risk.
掲載誌名
Frontiers in Psychiatry
ISSN
16640640
出版者
Frontiers Media S.A.
9
開始ページ
691
発行日
2018-12-12
権利情報
Copyright © 2018 Yamamoto, Sugaya, Siegle, Kumano, Shimada, Machado, Murillo-Rodriguez, Rocha, Nardi, Takamura, Okamoto and Yamawaki. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). (https://creativecommons.org/licenses/by/4.0/) The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
総合科学系