アクセス数 : ?
ダウンロード数 : ?
ID 114566
タイトル別表記
カフェイン酸フェネチルエステル(CAPE)がラット象牙芽細胞様細胞のVEGF発現と産生に与える影響
著者
蔵本, 瞳 徳島大学大学院口腔科学教育部(口腔科学専攻) 徳島大学 教育研究者総覧
Washio, Ayako Kyushu Dental University
Kitamura, Chiaki Kyushu Dental University
キーワード
Caffeic acid phenethyl ester (CAPE)
VEGF
odontoblast
KN-3
資料タイプ
学位論文
抄録
Caffeic acid phenethyl ester (CAPE), the main component of propolis, has various biological activities including anti-inflammatory effect and wound healing promotion. Odontoblasts located in the outermost layer of dental pulp play crucial roles such as production of growth factors and formation of hard tissue termed reparative dentin in host defense against dental caries. In this study, we investigated the effects of CAPE on the upregulation of vascular endothelial growth factor (VEGF) and calcification activities of odontoblasts, leading to development of novel therapy for dental pulp inflammation caused by dental caries. CAPE significantly induced mRNA expression and production of VEGF in rat clonal odontoblast-like KN-3 cells cultured in normal medium or osteogenic induction medium. CAPE treatment enhanced nuclear factor-kappa B (NF-κB) transcription factor activation, and furthermore, the specific inhibitor of NF-κB significantly reduced VEGF production. The expression of VEGF receptor- (VEGFR-) 2, not VEGFR-1, was up regulated in KN-3 cells treated with CAPE. In addition, VEGF significantly increased mineralization activity in KN-3 cells. These findings suggest that CAPE might be useful as a novel biological material for the dental pulp conservative therapy.
掲載誌名
BioMed Research International
ISSN
23146133
23146141
出版者
Hindawi
2019
開始ページ
5390720
発行日
2019-12-21
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Hitomi Kuramotoの学位論文として提出され, 学位審査・授与の対象となっている。
権利情報
© 2019 Hitomi Kuramoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3376号
学位記番号
甲口第455号
学位授与年月日
2020-03-23
学位名
博士(歯学)
学位授与機関
徳島大学
部局
歯学系
病院