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ID 114647
タイトル別表記
胎生期の低用量抗菌薬摂取が、子の腸内細菌叢や体脂肪組成に及ぼす影響
著者
吉本, 亜由美 徳島大学大学院栄養生命科学教育部(人間栄養科学専攻)
キーワード
CE-MS
DGGE
adiposity
maternal
transgenerational
資料タイプ
学位論文
抄録
Several environmental factors during the prenatal period transgenerationally affect the health of newborns in later life. Because low-dose antibiotics have been used for promoting the growth of crops and livestock in agriculture, humans may have ingested residual antibiotics for several decades. However, the effect of prenatal administration of low-dose antibiotics on newborns’ health in later life is unclear. In the present study, we found that prenatal treatment of murine mothers with low-dose antibiotics increased the abundance of bacteria of the phylum Firmicutes and the genera Clostridium IV and XIVa in feces from pups. In addition, the body fat percentage of mice in the antibiotic-treated group was higher than those in the control group at 12 weeks of age even though all pups were fed a standard diet. The body fat percentage of all mice was correlated with the abundance of fecal bacteria of Clostridium IV and XIVa. These results predict that low-dose antibiotic administration during the prenatal period affects the gut microbiota of newborns and possibly their health in later life.
掲載誌名
Journal of Clinical Biochemistry and Nutrition
ISSN
09120009
18805086
cat書誌ID
AA10710201
出版者
Society for Free Radical Research Japan
62
2
開始ページ
155
終了ページ
160
発行日
2018-03-01
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Ayumi Yoshimotoの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
© 2018 Society for Free Radical Research Japan
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3416号
学位記番号
甲栄第277号
学位授与年月日
2020-03-23
学位名
博士(栄養学)
学位授与機関
徳島大学
部局
医学系
生物資源系