アクセス数 : ?
ダウンロード数 : ?
ID 114662
タイトル別表記
健康成人におけるゼリータイプの炭水化物サプリメント摂取は脂肪組織と筋蛋白質の異化を抑制し満足度を改善した
著者
大山, 拓朗 徳島大学大学院医科学教育部(医学専攻) 徳島大学 教育研究者総覧
キーワード
Crossover design
Jelly-type oral nutritional supplement
Metabolism
Antioxidation
ERAS
資料タイプ
学位論文
抄録
Background & aims: Many studies have reported the effects of preoperative clear fluid carbohydrate supplements; however, few studies have reported the effects of preoperative jelly-type carbohydrate supplements. This study aimed to assess the effect of a jelly-type oral nutritional supplement (ONS) on metabolism, redox balance by using various surrogate markers and to evaluate its excretion from the stomach.
Methods: This study was conducted according to a crossover design. Participants underwent a control experiment whereby they fasted after dinner and only ingested water until the experiment. The remaining participants underwent an ONS experiment whereby they ingested 400 g of ONS before bed and another 400 g at 7:00 am. Blood samples were collected at 9:00 am. After a break of at least 24 h, participants underwent the alternate experiment.
Results: Thirty minutes after intake of jelly, the gastric antrum appeared flat (the same result as that at baseline) on ultrasonography. The ONS group showed significantly lower serum free fatty acid levels (100 μEq/L, p = 0.027, vs. 327 μEq/L, n = 6), total ketone bodies levels, 3-MH/creatinine levels, and oxidative stress surrogate markers. Serum insulin levels were significantly higher and participant's satisfaction was improved in the ONS group.
Conclusions: We have the limitations of our methodologies as surrogate markers, compared with direct measurement of lipolysis, proteolysis and redox balance regulation. But Jelly-type ONS suppresses the catabolism of adipose tissue and muscle protein, decreases oxidative stress and improves patient satisfaction in healthy participants, without any increased risk of aspiration.
掲載誌名
Clinical Nutrition Experimental
ISSN
23529393
出版者
Elsevier|European Society for Clinical Nutrition and Metabolism
19
開始ページ
1
終了ページ
11
発行日
2018-04-10
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Takuro Oyamaの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
© 2018 The Authors. Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3357号
学位記番号
甲医第1440号
学位授与年月日
2020-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系