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ID 114872
著者
藤井, 笑子 The University of Tokushima
Miyazaki, Masahito The University of Tokushima
橋本, 俊顕 Japanese Red Cross Tokushima Hinomine Rehabilitation
キーワード
Autistic spectrum disorders (ASD)
123I-iomazenil SPECT
γ-Aminobutyric acid (GABA)
Epilepsy
資料タイプ
学術雑誌論文
抄録
Purpose:
To evaluate the GABAA receptor in the autistic brain, we performed 123I-IMZ SPECT in patients with ASD. We compared 123I-IMZ SPECT abnormalities in patients who showed intellectual disturbance or focal epileptic discharge on EEG to those in patients without such findings.
Subjects and methods:
The subjects consisted of 24 patients with ASD (mean age, 7.3±3.5years), including 9 with autistic disorder (mean age, 7.0±3.7years) and 15 with Asperger’s disorder (mean age, 7.5±3.2years). We used 10 non-symptomatic partial epilepsy patients (mean age, 7.8±3.6years) without intellectual delay as a control group.
For an objective evaluation of the 123I-IMZ SPECT results, we performed an SEE (Stereotactic Extraction Estimation) analysis to describe the decrease in accumulation in each brain lobule numerically.
Results
In the comparison of the ASD group and the control group, there was a dramatic decrease in the accumulation of 123I-IMZ in the superior and medial frontal cortex. In the group with intellectual impairment and focal epileptic discharge on EEG, the decrease in accumulation in the superior and medial frontal cortex was greater than that in the group without these findings.
Conclusion
The present results suggest that disturbance of the GABAergic nervous system may contribute to the pathophysiology and aggravation of ASD, since the accumulation of 123I-IMZ was decreased in the superior and medial frontal cortex, which is considered to be associated with inference of the thoughts, feelings, and intentions of others (Theory of Mind).
掲載誌名
Brain and Development
ISSN
03877604
cat書誌ID
AA00111153
AA11521714
出版者
The Japanese Society of Child Neurology|Elsevier
34
8
開始ページ
648
終了ページ
654
発行日
2011-11-17
権利情報
© 2011. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
病院
医学系