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ID 114906
タイトル別表記
Zolpidem therapy in dystonia
著者
宮﨑, 由道 University of Tokushima|Ehime University KAKEN研究者をさがす
浅沼, 光太郎 University of Tokushima
Miki, Tetsuro Ehime University
キーワード
generalized dystonia
Meige syndrome
hand dystonia
zolpidem
資料タイプ
学術雑誌論文
抄録
Although there are some newly developed options to treat dystonia, its medical treatment is not always satisfactory. Zolpidem, an imidazopyridine agonist with a high affinity on benzodiazepine subtype receptor BZ1 (ω1), was found to improve clinical symptoms of dystonia in a limited number of case reports. To investigate what subtype of dystonia is responsive to the therapy, we conducted an open label study to assess the efficacy of zolpidem (5–20 mg) in 34 patients suffering from miscellaneous types of dystonia using the Burke–Fahn–Marsden Dystonia Rating Scale (BFMDRS). Patients were entered into the study if they had been refractory to other medications as evaluated by BFMDRS (no change in the previous two successive visits). After zolpidem therapy, the scores in the patients as a whole were decreased from 7.2 ± 7.9 to 5.5 ± 5.0 (P = 0.042). Patients with generalized dystonia, Meige syndrome/blepharospasm, and hand dystonia improved in the scale by 27.8, 17.8, and 31.0%, respectively, whereas no improvement was found in cervical dystonia patients. Overall response rate among patients were comparable to that of trihexyphenidyl. Zolpidem may be a therapeutic option for generalized dystonia, Meige syndrome, and hand dystonia including musician’s. Drowsiness was the dose-limiting factor.
掲載誌名
Frontiers in Neurology
ISSN
16642295
出版者
Frontiers Media S.A.
3
開始ページ
58
発行日
2012-04-17
権利情報
© 2012 Miyazaki, Sako, Asanuma, Izumi, Miki and Kaji. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License(https://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
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出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系