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ID 114907
タイトル別表記
ATP and sleep
著者
近久, 幸子 The University of Tokushima KAKEN研究者をさがす
キーワード
sleep
ATP
adenosine
astrocyte
AMPK
資料タイプ
学術雑誌論文
抄録
One of the functions of sleep is to maintain energy balance in the brain. There are a variety of hypotheses related to how metabolic pathways interact with sleep/wake regulation. A major finding that demonstrates an interaction between sleep and metabolic homeostasis is the involvement of adenosine in sleep homeostasis. An accumulation of adenosine is supplied from ATP, which can act as an energy currency in the cell. Extracellularly, ATP can act as an activity-dependent signaling molecule, especially in regard to communication between neurons and glia, including astrocytes. Furthermore, the intracellular AMP/ATP ratio controls the activity of AMP-activated protein kinase, which is a potent energy regulator and is recently reported to play a role in the regulation of sleep homeostasis. Brain ATP may support multiple functions in the regulation of the sleep/wake cycle and sleep homeostasis.
掲載誌名
Frontiers in Neurology
ISSN
16642295
出版者
Frontiers Media S.A.
2
開始ページ
87
発行日
2011-12-27
権利情報
© 2011 Chikahisa and Séi. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License(https://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系