アクセス数 : ?
ダウンロード数 : ?
ID 115050
著者
Hashimoto, Osamu Kitasato University
Funaba, Masayuki Kyoto University
Sekiyama, Kazunari Kitasato University
Doi, Satoru Kitasato University
Shindo, Daichi Kitasato University
Satoh, Ryo Kitasato University
Itoi, Hiroshi Kitasato University
Oiwa, Hiroaki Kitasato University
Morita, Masahiro Kitasato University
Suzuki, Chisato Kitasato University
Sugiyama, Makoto Kitasato University
Yamakawa, Norio National Institute of Advanced Industrial Science and Technology
Takada, Hitomi National Institute of Advanced Industrial Science and Technology|Nara Institute of Science and Technology
Matsumura, Shigenobu Kyoto University
Inoue, Kazuo Kyoto University
Sugino, Hiromu National Institute of Advanced Industrial Science and Technology|Tokyo Metropolitan Institute of Medical Science
Kurisaki, Akira National Institute of Advanced Industrial Science and Technology|Nara Institute of Science and Technology
資料タイプ
学術雑誌論文
抄録
Brown adipocyte activation or beige adipocyte emergence in white adipose tissue (WAT) increases energy expenditure, leading to a reduction in body fat mass and improved glucose metabolism. We found that activin E functions as a hepatokine that enhances thermogenesis in response to cold exposure through beige adipocyte emergence in inguinal WAT (ingWAT). Hepatic activin E overexpression activated thermogenesis through Ucp1 upregulation in ingWAT and other adipose tissues including interscapular brown adipose tissue and mesenteric WAT. Hepatic activin E-transgenic mice exhibited improved insulin sensitivity. Inhibin βE gene silencing inhibited cold-induced Ucp1 induction in ingWAT. Furthermore, in vitro experiments suggested that activin E directly stimulated expression of Ucp1 and Fgf21, which was mediated by transforming growth factor-β or activin type I receptors. We uncovered a function of activin E to stimulate energy expenditure through brown and beige adipocyte activation, suggesting a possible preventive or therapeutic target for obesity.
掲載誌名
Cell Reports
ISSN
22111247
出版者
Elsevier
25
5
開始ページ
1193
終了ページ
1203
発行日
2018-10-30
権利情報
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
先端酵素学研究所