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ID 115179
著者
Tokuoka, Atsushi Okayama University
Bando, Tetsuya Okayama University
Tomioka, Kenji Okayama University
キーワード
Circadian rhythm
Photoperiodic modulation
Histone modification
Clock gene
Enhancer of zeste
資料タイプ
学術雑誌論文
抄録
Introduction: Insects show daily behavioral rhythms controlled by an endogenous oscillator, the circadian clock. The rhythm synchronizes to daily light–dark cycles (LD) and changes waveform in association with seasonal change in photoperiod.
Results: To explore the molecular basis of the photoperiod-dependent changes in circadian locomotor rhythm, we investigated the role of a chromatin modifier, Enhancer of zeste (Gb’E(z)), in the cricket, Gryllus bimaculatus. Under a 12 h:12 h LD (LD 12:12), Gb’E(z) was constitutively expressed in the optic lobe, the site of the biological clock; active phase (α) and rest phase (ρ) were approximately 12 h in duration, and α/ρ ratio was approximately 1.0. When transferred to LD 20:4, the α/ρ ratio decreased significantly, and the Gb’E(z) expression level was significantly reduced at 6 h and 10 h after light-on, as was reflected in the reduced level of trimethylation of histone H3 lysine 27. This change was associated with change in clock gene expression profiles. The photoperiod-dependent changes in α/ρ ratio and clock gene expression profiles were prevented by knocking down Gb’E(z) by RNAi.
Conclusions: These results suggest that histone modification by Gb’E(z) is involved in photoperiodic modulation of the G. bimaculatus circadian rhythm.
掲載誌名
Zoological Letters
ISSN
2056306X
出版者
Springer Nature|BioMed Central
2
開始ページ
5
発行日
2016-03-19
権利情報
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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フルテキストファイル
zl_2_5.pdf 2.32 MB
言語
eng
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出版社版
部局
先端酵素学研究所
生物資源系