直近一年間の累計
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ID 115632
著者
Furukawa, Koichi Chubu University|Nagoya University
Ohmi, Yuhsuke Chubu University
Yesmin, Farhana Chubu University|Nagoya University
Tajima, Orie Chubu University
Kondo, Yuji Nagoya University
Zhang, Pu Chubu University|Nagoya University
Ohkawa, Yuki Osaka International Cancer Institute
Bhuiyan, Robiul H. Chubu University
Furukawa, Keiko Chubu University
キーワード
ganglioside
knockout
neurodegeneration
glycosphingolipid
inflammation
microdomain
資料タイプ
学術雑誌論文
抄録
Acidic glycosphingolipids, i.e., gangliosides, are predominantly and consistently expressed in nervous tissues of vertebrates at high levels. Therefore, they are considered to be involved in the development and function of nervous systems. Recent studies involving genetic engineering of glycosyltransferase genes have revealed novel aspects of the roles of gangliosides in the regulation of nervous tissues. In this review, novel findings regarding ganglioside functions and their modes of action elucidated mainly by studies of gene knockout mice are summarized. In particular, the roles of gangliosides in the regulation of lipid rafts to maintain the integrity of nervous systems are reported with a focus on the roles in the regulation of neuro-inflammation and neurodegeneration via complement systems. In addition, recent advances in studies of congenital neurological disorders due to genetic mutations of ganglioside synthase genes and also in the techniques for the analysis of ganglioside functions are introduced.
掲載誌名
International Journal of Molecular Sciences
ISSN
14220067
16616596
cat書誌ID
AA12038549
出版者
MDPI
21
6
開始ページ
1906
発行日
2020-03-11
権利情報
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系