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ID 115698
著者
Irieda, Hiroki Kyoto University|Shinshu University
Inoue, Yoshihiro Kyoto University
Mori, Masashi Ishikawa Prefectural University
山田, 晃嗣 Kyoto University|Tokushima University 徳島大学 教育研究者総覧
Oshikawa, Yuu Ishikawa Prefectural University
Saitoh, Hiromasa Tokyo University of Agriculture|Iwate Biotechnology Research Center
Uemura, Aiko Iwate Biotechnology Research Center
Terauchi, Ryohei Kyoto University|Iwate Biotechnology Research Center
Kitakura, Saeko Kyoto University
Kosaka, Ayumi Kyoto University
Singkaravanit-Ogawa, Suthitar Kyoto University
Takano, Yoshitaka Kyoto University
キーワード
BAK1
BIK1
core effector
PAMP-triggered immunity
phytopathogenic fungi
資料タイプ
学術雑誌論文
抄録
Plant pathogens have optimized their own effector sets to adapt to their hosts. However, certain effectors, regarded as core effectors, are conserved among various pathogens, and may therefore play an important and common role in pathogen virulence. We report here that the widely distributed fungal effector NIS1 targets host immune components that transmit signaling from pattern recognition receptors (PRRs) in plants. NIS1 from two Colletotrichum spp. suppressed the hypersensitive response and oxidative burst, both of which are induced by pathogen-derived molecules, in Nicotiana benthamiana. Magnaporthe oryzae NIS1 also suppressed the two defense responses, although this pathogen likely acquired the NIS1 gene via horizontal transfer from Basidiomycota. Interestingly, the root endophyte Colletotrichum tofieldiae also possesses a NIS1 homolog that can suppress the oxidative burst in N. benthamiana. We show that NIS1 of multiple pathogens commonly interacts with the PRR-associated kinases BAK1 and BIK1, thereby inhibiting their kinase activities and the BIK1-NADPH oxidase interaction. Furthermore, mutations in the NIS1-targeting proteins, i.e., BAK1 and BIK1, in Arabidopsis thaliana also resulted in reduced immunity to Colletotrichum fungi. Finally, M. oryzae lacking NIS1 displayed significantly reduced virulence on rice and barley, its hosts. Our study therefore reveals that a broad range of filamentous fungi maintain and utilize the core effector NIS1 to establish infection in their host plants and perhaps also beneficial interactions, by targeting conserved and central PRR-associated kinases that are also known to be targeted by bacterial effectors.
掲載誌名
Proceedings of the National Academy of Sciences of the United States of America
ISSN
10916490
cat書誌ID
AA11726874
AA12104563
出版者
National Academy of Sciences
116
2
開始ページ
496
終了ページ
505
発行日
2018-12-24
権利情報
This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND)(https://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
生物資源系