ID | 115698 |
著者 |
Irieda, Hiroki
Kyoto University|Shinshu University
Inoue, Yoshihiro
Kyoto University
Mori, Masashi
Ishikawa Prefectural University
Oshikawa, Yuu
Ishikawa Prefectural University
Saitoh, Hiromasa
Tokyo University of Agriculture|Iwate Biotechnology Research Center
Uemura, Aiko
Iwate Biotechnology Research Center
Terauchi, Ryohei
Kyoto University|Iwate Biotechnology Research Center
Kitakura, Saeko
Kyoto University
Kosaka, Ayumi
Kyoto University
Singkaravanit-Ogawa, Suthitar
Kyoto University
Takano, Yoshitaka
Kyoto University
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キーワード | BAK1
BIK1
core effector
PAMP-triggered immunity
phytopathogenic fungi
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資料タイプ |
学術雑誌論文
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抄録 | Plant pathogens have optimized their own effector sets to adapt to their hosts. However, certain effectors, regarded as core effectors, are conserved among various pathogens, and may therefore play an important and common role in pathogen virulence. We report here that the widely distributed fungal effector NIS1 targets host immune components that transmit signaling from pattern recognition receptors (PRRs) in plants. NIS1 from two Colletotrichum spp. suppressed the hypersensitive response and oxidative burst, both of which are induced by pathogen-derived molecules, in Nicotiana benthamiana. Magnaporthe oryzae NIS1 also suppressed the two defense responses, although this pathogen likely acquired the NIS1 gene via horizontal transfer from Basidiomycota. Interestingly, the root endophyte Colletotrichum tofieldiae also possesses a NIS1 homolog that can suppress the oxidative burst in N. benthamiana. We show that NIS1 of multiple pathogens commonly interacts with the PRR-associated kinases BAK1 and BIK1, thereby inhibiting their kinase activities and the BIK1-NADPH oxidase interaction. Furthermore, mutations in the NIS1-targeting proteins, i.e., BAK1 and BIK1, in Arabidopsis thaliana also resulted in reduced immunity to Colletotrichum fungi. Finally, M. oryzae lacking NIS1 displayed significantly reduced virulence on rice and barley, its hosts. Our study therefore reveals that a broad range of filamentous fungi maintain and utilize the core effector NIS1 to establish infection in their host plants and perhaps also beneficial interactions, by targeting conserved and central PRR-associated kinases that are also known to be targeted by bacterial effectors.
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掲載誌名 |
Proceedings of the National Academy of Sciences of the United States of America
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ISSN | 10916490
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cat書誌ID | AA11726874
AA12104563
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出版者 | National Academy of Sciences
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巻 | 116
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号 | 2
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開始ページ | 496
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終了ページ | 505
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発行日 | 2018-12-24
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権利情報 | This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND)(https://creativecommons.org/licenses/by-nc-nd/4.0/).
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
生物資源系
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