ID | 115714 |
著者 |
Nakazawa, Takanobu
Osaka University
Kikuchi, Masataka
Osaka University
Ishikawa, Mitsuru
Keio University
Yamamori, Hidenaga
Osaka University
Nagayasu, Kazuki
Osaka University
Matsumoto, Takuya
Keio University|Ajinomoto
Fujimoto, Michiko
Osaka University
Yasuda, Yuka
Osaka University
Fujiwara, Mikiya
Osaka University
Okada, Shota
Osaka University
Matsumura, Kensuke
Osaka University
Kasai, Atsushi
Osaka University
Hayata-Takano, Atsuko
Osaka University
Shintani, Norihito
Osaka University
Takuma, Kazuhiro
Osaka University
Akamatsu, Wado
Keio University|Juntendo University
Okano, Hideyuki
Keio University
Nakaya, Akihiro
Osaka University
Hashimoto, Hitoshi
Osaka University
Hashimoto, Ryota
Osaka University
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キーワード | iPS cell
Monozygotic twins
Treatment-resistant schizophrenia
Clozapine
Drug response
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資料タイプ |
学術雑誌論文
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抄録 | Schizophrenia is a chronic psychiatric disorder with complex genetic and environmental origins. While many antipsychotics have been demonstrated as effective in the treatment of schizophrenia, a substantial number of schizophrenia patients are partially or fully unresponsive to the treatment. Clozapine is the most effective antipsychotic drug for treatment-resistant schizophrenia; however, clozapine has rare but serious side-effects. Furthermore, there is inter-individual variability in the drug response to clozapine treatment. Therefore, the identification of the molecular mechanisms underlying the action of clozapine and drug response predictors is imperative. In the present study, we focused on a pair of monozygotic twin cases with treatment-resistant schizophrenia, in which one twin responded well to clozapine treatment and the other twin did not. Using induced pluripotent stem (iPS) cell-based technology, we generated neurons from iPS cells derived from these patients and subsequently performed RNA-sequencing to compare the transcriptome profiles of the mock or clozapine-treated neurons. Although, these iPS cells similarly differentiated into neurons, several genes encoding homophilic cell adhesion molecules, such as protocadherin genes, showed differential expression patterns between these two patients. These results, which contribute to the current understanding of the molecular mechanisms of clozapine action, establish a new strategy for the use of monozygotic twin studies in schizophrenia research.
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掲載誌名 |
Schizophrenia Research
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ISSN | 09209964
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cat書誌ID | AA10703465
AA11539775
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出版者 | Elsevier
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巻 | 181
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開始ページ | 75
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終了ページ | 82
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発行日 | 2016-10-27
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権利情報 | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
医学系
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