内分泌療法を行った高齢者ホルモン受容体陽性乳癌非手術例の検討

The treatment of breast cancer in elderly patients is usually surgery, and in the Japanese Breast Cancer Society Clinical Practice Guidelines for Breast Cancer, the use of only drug therapy is limited to cases of co-morbidities or refusal of surgery. However, there are many cases in which surgery is not performed due to co-morbidities and in which the patient or patient's family declines surgery. We retrospectively analyzed the cases of 19 elderly patients aged 75 or above with hormone receptor-positive breast cancer who selected endocrine therapy as early treatment at our hospital or Yamakawa Breast Clinic during the period from December 2009 to December 2019. We determined the treatment effects, changes in the patients' quality of life (QOL), co-morbidities, medication compliance, and more. Six patients died due to causes other than breast cancer, and one case of death due to breast cancer was confirmed. These results indicate that endocrine therapy can contribute to good progress and QOL maintenance. We suggest that selecting only endocrine therapy as early treatment can be an appropriate option for elderly patients with hormone receptor-positive breast cancer when their daily life can be monitored by their family members.