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ID 116142
著者
Kawamoto, Emi Nagaoka College
Koshinaka, Keiichi Niigata University of Health and Welfare
Iwabe, Maiko Sapporo University of Health Sciences
Tomiga, Yuki Fukuoka University|Fukuoka University
Iizawa, Hiroki Fukuoka University
Honda, Hiroki Fukuoka University
Higaki, Yasuki Fukuoka University
Kawanaka, Kentaro Fukuoka University
キーワード
AMP-activated protein kinase
epitrochlearis
soleus
swimming
treadmill running
資料タイプ
学術雑誌論文
抄録
We previously reported that in rat skeletal muscle, disuse (i.e., decreased muscle contractile activity) rapidly increases thioredoxin-interacting protein (TXNIP), which is implicated in the reduced glucose uptake. Accordingly, we sought herein to (a) determine the effect of exercise (i.e., increased muscle contractile activity) on muscle TXNIP protein expression, and (b) elucidate the mechanisms underlying the changes of TXNIP protein expression in response to exercise. Rat epitrochlearis and soleus muscles were dissected out after an acute bout of 3-hr swimming (without weight loading) or 3-hr treadmill running (15% grade at 9m/min). In a separate protocol, the isolated epitrochlearis and soleus muscles were incubated for 3 hr with AMP-dependent protein kinase activator AICAR. Immediately after the cessation of the 3-hr swimming, the TXNIP protein was decreased in epitrochlearis but not in soleus muscle. Conversely, 3-hr treadmill running decreased the TXNIP protein in soleus but not in epitrochlearis muscle. TXNIP protein was decreased concomitantly with reduced postexercise muscle glycogen, showing that a decrease in TXNIP protein expression occurs in muscles that are recruited during exercise. In addition, 3-hr incubation with AICAR decreased TXNIP protein in both isolated epitrochlearis and soleus muscles. Our results suggest that (a) an acute bout of exercise downregulates TXNIP protein expression in rat contracting skeletal muscles, and (b) the reduction in TXNIP protein expression in contracting muscles is probably mediated by AMPK activation, at least in part.
掲載誌名
Physiological Reports
ISSN
2051817X
出版者
Wiley|The Physiological Society|The American Physiological Society
8
11
開始ページ
e14388
発行日
2020-05-31
権利情報
This is an open access article under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
教養教育院