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ID 116603
著者
Mochizuki, Takashi Tokushima University
Lila, Amr S. Abu Zagazig University|Hail University
Akagi, Shunsuke Tokushima University
Tajima, Kenji Hokkaido University
Fujita, Kenji Tokushima University
Matsushima, Tokuo Kusano Sakko
Kusano, Takatomo Kusano Sakko
キーワード
nanofibrillated bacterial cellulose
bacterial cellulose
peritoneally disseminated gastric cancer
doxorubicin
intraperitoneal chemotherapy
資料タイプ
学術雑誌論文
抄録
Natural materials such as bacterial cellulose are gaining interest for their use as drug-delivery vehicles. Herein, the utility of nanofibrillated bacterial cellulose (NFBC), which is produced by culturing a cellulose-producing bacterium (Gluconacetobacter intermedius NEDO-01) in a medium supplemented with carboxymethylcellulose (CMC) that is referred to as CM-NFBC, is described. Recently, we demonstrated that intraperitoneal administration of paclitaxel (PTX)-containing CM-NFBC efficiently suppressed tumor growth in a peritoneally disseminated cancer xenograft model. In this study, to confirm the applicability of NFBC in cancer therapy, a chemotherapeutic agent, doxorubicin (DXR), embedded into CM-NFBC, was examined for its efficiency to treat a peritoneally disseminated gastric cancer via intraperitoneal administration. DXR was efficiently embedded into CM-NFBC (DXR/CM-NFBC). In an in vitro release experiment, 79.5% of DXR was released linearly into the peritoneal wash fluid over a period of 24 h. In the peritoneally disseminated gastric cancer xenograft model, intraperitoneal administration of DXR/CM-NFBC induced superior tumor growth inhibition (TGI = 85.5%) by day 35 post-tumor inoculation, compared to free DXR (TGI = 62.4%). In addition, compared with free DXR, the severe side effects that cause body weight loss were lessened via treatment with DXR/CM-NFBC. These results support the feasibility of CM-NFBC as a drug-delivery vehicle for various anticancer agents. This approach may lead to improved therapeutic outcomes for the treatment of intraperitoneally disseminated cancers.
掲載誌名
Nanomaterials
ISSN
20794991
出版者
MDPI
11
7
開始ページ
1697
発行日
2021-06-28
権利情報
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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言語
eng
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出版社版
部局
薬学系