ID | 116825 |
著者 |
Sasaki, Shota
Tohoku University
Zheng, Yuexing
Tohoku University
Mokudai, Takayuki
Tohoku University
Kanetaka, Hiroyasu
Tohoku University
Kanzaki, Makoto
Tohoku University
Kaneko, Toshiro
Tohoku University
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キーワード | atmospheric pressure plasma
Ca2+ signaling
peroxynitrite
plasma medicine
TRP channel
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資料タイプ |
学術雑誌論文
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抄録 | Although the externally controllable extracellular supply of the short-lived reactive oxygen and nitrogen species, such as O2•−, •NO, and ONOO−, could potentially manipulate cellular functions, their simple administration to cells is likely to be ineffective due to their rapid deactivation. In this study, we found a method of a continuous supply of O2•−/ONOO− over a few minutes, which is triggered by irradiation of a nonequilibrium atmospheric pressure plasma to commonly used organic buffers (e.g., 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, HEPES). In addition, a continuous low-dose O2•−/ONOO− supply was shown to induce a physiologically relevant Ca2+ response and subsequently the uptake of a large cation mediated by transient receptor potential channel family member(s). Our results provide a novel approach to the continuous O2•−/ONOO− supply, requiring controllable and mass-volume treatments.
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掲載誌名 |
Plasma Processes and Polymers
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ISSN | 16128869
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cat書誌ID | AA11976237
AA1281120X
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出版者 | Wiley‐VCH
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巻 | 17
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号 | 10
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開始ページ | e1900257
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発行日 | 2020-05-25
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権利情報 | This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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言語 |
eng
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著者版フラグ |
出版社版
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部局 |
薬学系
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