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ID 116825
著者
Sasaki, Shota Tohoku University
Zheng, Yuexing Tohoku University
Mokudai, Takayuki Tohoku University
Kanetaka, Hiroyasu Tohoku University
Kanzaki, Makoto Tohoku University
Kaneko, Toshiro Tohoku University
キーワード
atmospheric pressure plasma
Ca2+ signaling
peroxynitrite
plasma medicine
TRP channel
資料タイプ
学術雑誌論文
抄録
Although the externally controllable extracellular supply of the short-lived reactive oxygen and nitrogen species, such as O2•−, •NO, and ONOO−, could potentially manipulate cellular functions, their simple administration to cells is likely to be ineffective due to their rapid deactivation. In this study, we found a method of a continuous supply of O2•−/ONOO− over a few minutes, which is triggered by irradiation of a nonequilibrium atmospheric pressure plasma to commonly used organic buffers (e.g., 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, HEPES). In addition, a continuous low-dose O2•−/ONOO− supply was shown to induce a physiologically relevant Ca2+ response and subsequently the uptake of a large cation mediated by transient receptor potential channel family member(s). Our results provide a novel approach to the continuous O2•−/ONOO− supply, requiring controllable and mass-volume treatments.
掲載誌名
Plasma Processes and Polymers
ISSN
16128869
cat書誌ID
AA11976237
AA1281120X
出版者
Wiley‐VCH
17
10
開始ページ
e1900257
発行日
2020-05-25
権利情報
This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
薬学系