Relationship between quality of life and clinical factors in inpatients with schizophrenia

Objective : The purpose of this study was to clarify the relationship between quality of life (QOL) and clinical factors in inpatients with schizophrenia. Methods : Subjects were 50 hospitalized patients with schizophrenia. Their mean age was 56.48 (Standard Deviation = 11.93) years. Japanese version of the schizophrenia Quality of Life Scale (JSQLS) and Subjective Well-being under Neuroleptic drug Treatment Short form, Japanese version (SWNS-J) were used to assess subjective QOL, and Mini Mental State Examination-Japanese was used to evaluate cognitive function. Japanese version of the Calgary Depression Scale for Schizophrenia (JCDSS), Brief Psychiatric Rating Scale, and Drug-Induced Extrapyramidal Symptoms Scale were used to assess depression severity, psychotic symptoms, and drug-induced extrapyramidal symptoms, respectively. Stepwise regression analyses were conducted to find factors influencing JSQLS and SWNS-J. Results : JCDSS was a predictor of two scales of JSQLS, and JCDSS also predicted SWNS-J Total and it’s two subscales. However, other clinical factors were not related to JSQLS and SWNS-J. Conclusion : The results indicate that treating depressive symptoms may lead to improvement of subjective QOL in inpatients with schizophrenia.