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ID 117445
著者
Tanaka, Yoshiaki Tokushima University
Okuyama, Hitomi Tokushima University
Nishikawa, Miyu Toyama Prefectural University
Ikushiro, Shin-ichi Toyama Prefectural University
Ikeda, Mayumi Tokushima University
Ukawa, Yuichi Daicel Corporation
Oe, Kenichi Daicel Corporation
キーワード
8-prenylnaringenin
naringenin
pharmacokinetics
serum albumin
tissue accumulation
資料タイプ
学術雑誌論文
抄録
8-Prenylnaringenin (8-PN), a hop flavonoid, is a promising food substance with health benefits. Compared with nonprenylated naringenin, 8-PN exhibits stronger estrogenic activity and prevents muscle atrophy. Moreover, 8-PN prevents hot flushes and bone loss. Considering that prenylation reportedly improves the bioavailability of flavonoids, we compared the parameters related to the bioavailability [pharmacokinetics and tissue distribution in C57/BL6 mice, binding affinity to human serum albumin (HSA), and cellular uptake in HEK293 cells] of 8-PN and its mother (non-prenylated) compound naringenin. C57/BL6 mice were fed an 8-PN or naringenin mixed diet for 22 days. The amount of 8-PN (nmol/g tissue) in the kidneys (16.8 ± 9.20), liver (14.8 ± 2.58), muscles (3.33 ± 0.60), lungs (2.07 ± 0.68), pancreas (1.80 ± 0.38), heart (1.71 ± 0.27), spleen (1.36 ± 0.29), and brain (0.31 ± 0.09) was higher than that of naringenin. A pharmacokinetic study in mice demonstrated that the Cmax of 8-PN (50 mg/kg body weight) was lower than that of naringenin; however, the plasma concentration of 8-PN 8 h after ingestion was higher than that of naringenin. The binding affinity of 8-PN to HSA and cellular uptake in HEK293 cells were higher than those of naringenin. 8-PN bioavailability features assessed in mouse or human model experiments were obviously different from those of naringenin.
掲載誌名
Food Science & Nutrition
ISSN
20487177
出版者
Wiley Periodicals
10
4
開始ページ
1070
終了ページ
1080
発行日
2022-01-22
権利情報
This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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出版社版DOI
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フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
薬学系
医学系
生物資源系