ID | 117745 |
著者 |
Hori, Hiroyuki
Ehime University
Kawamura, Takuya
Ehime University
Awai, Takako
Ehime University
Ochi, Anna
Ehime University
Yamagami, Ryota
Ehime University
Tomikawa, Chie
Ehime University
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キーワード | archaea
methylation
pseudouridine
RNA modification
tRNA methyltransferase
tRNA modification
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資料タイプ |
学術雑誌論文
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抄録 | To date, numerous modified nucleosides in tRNA as well as tRNA modification enzymes have been identified not only in thermophiles but also in mesophiles. Because most modified nucleosides in tRNA from thermophiles are common to those in tRNA from mesophiles, they are considered to work essentially in steps of protein synthesis at high temperatures. At high temperatures, the structure of unmodified tRNA will be disrupted. Therefore, thermophiles must possess strategies to stabilize tRNA structures. To this end, several thermophile-specific modified nucleosides in tRNA have been identified. Other factors such as RNA-binding proteins and polyamines contribute to the stability of tRNA at high temperatures. Thermus thermophilus, which is an extreme-thermophilic eubacterium, can adapt its protein synthesis system in response to temperature changes via the network of modified nucleosides in tRNA and tRNA modification enzymes. Notably, tRNA modification enzymes from thermophiles are very stable. Therefore, they have been utilized for biochemical and structural studies. In the future, thermostable tRNA modification enzymes may be useful as biotechnology tools and may be utilized for medical science.
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掲載誌名 |
Microorganisms
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ISSN | 20762607
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出版者 | MDPI
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巻 | 6
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号 | 4
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開始ページ | 110
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発行日 | 2018-10-20
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権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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言語 |
eng
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著者版フラグ |
出版社版
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部局 |
理工学系
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