ID | 117809 |
タイトル別表記 | Novel Lipid Risk Stratification for CAD
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著者 |
Abe, Shichiro
Dokkyo Medical University
Haruyama, Yasuo
Dokkyo Medical University
Kobashi, Gen
Dokkyo Medical University
Toyoda, Shigeru
Dokkyo Medical University
Inoue, Teruo
Dokkyo Medical University|Nasu Red Cross Hospital
Tomiyama, Hirofumi
Tokyo Medical University
Ishizu, Tomoko
University of Tsukuba
Kohro, Takahide
Jichi Medical University
Higashi, Yukihito
Research Institute for Radiation Biology and Medicine
Takase, Bonpei
National Defense Medical College Research Institute
Suzuki, Toru
University of Leicester
Ueda, Shinichiro
University of the Ryukyus
Yamazaki, Tsutomu
The University of Tokyo
Furumoto, Tomoo
NTT Medical Center Sapporo
Kario, Kazuomi
Jichi Medical University
Koba, Shinji
Showa University
Takemoto, Yasuhiko
Osaka City University
Hano, Takuzo
Wakayama Medical University
Ishibashi, Yutaka
Shimane University
Node, Koichi
Saga University
Maemura, Koji
Nagasaki University
Ohya, Yusuke
University of the Ryukyus
Furukawa, Taiji
Teikyo University
Ito, Hiroshi
Okayama University
Yamashina, Akira
Tokyo Medical University
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キーワード | Coronary artery disease
Flow-mediated dilation
Lipid risk stratification
Non-high-density lipoprotein cholesterol
Triglyceride
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資料タイプ |
学術雑誌論文
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抄録 | Background: Elevated levels of triglyceride (TG) and non-high-density lipoprotein cholesterol (non-HDL-C) are regarded as a residual lipid risk in low-density lipoprotein cholesterol (LDL-C)-lowering therapy. This study investigated the association between lipid risk stratified by TG and non-HDL-C and the prognosis of patients with coronary artery disease (CAD), and the association between stratified lipid risk and flow-mediated dilatation (FMD) index.
Methods and Results: The 624 CAD patients enrolled in flow-mediated dilation (FMD)-J study A were divided into 4 groups: low-risk group (n=413) with TG <150 mg/dL and non-HDL-C <170 mg/dL; hyper-TG group (n=180) with TG ≥150 mg/dL and non-HDL-C <170 mg/dL; hyper-non-HDL group (n=12) with TG <150 mg/dL and non-HDL-C ≥170 mg/dL; and high-risk group (n=19) with TG ≥150 mg/dL and non-HDL-C ≥170 mg/dL. Comparison of the groups showed the cumulative incidence of a 3-point major adverse cardiovascular event (MACE) was different and highest in the high-risk group in all the patients (P=0.009), and in patients with a FMD index ≥7.0% (P=0.021), but not in those with a FMD index <7.0%. Multivariable regression analysis showed that high lipid risk (P=0.019) and FMD <7.0% (P=0.040) were independently correlated with the incidence of a 3-point MACE. Conclusions: Novel stratification of lipid risk, simply using TG and non-HDL-C levels, combined with FMD measurement, is useful for predicting cardiovascular outcomes in patients with CAD. |
掲載誌名 |
Circulation Journal
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ISSN | 13474820
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出版者 | The Japanese Circulation Society
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巻 | 86
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号 | 9
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開始ページ | 1444
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終了ページ | 1454
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発行日 | 2022-08-25
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権利情報 | This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license. https://creativecommons.org/licenses/by-nc-nd/4.0/
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言語 |
eng
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著者版フラグ |
出版社版
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部局 |
医学系
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