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ID 118315
タイトル別表記
食餌性リンはマウスの腸内環境を変化させる
著者
織田, 奈央子 徳島大学大学院医科栄養学研究科(医科栄養学専攻)
Sugihara, Kohei Tokushima University
大西, 康太 Tokushima University
キーワード
hyperphosphatemia
microbiota
chronic kidney disease
tight junction
short chain fatty acids
資料タイプ
学位論文
抄録
Disorder of phosphate metabolism is a common pathological condition in chronic kidney disease patients. Excessive intake of dietary phosphate deteriorates chronic kidney disease and various complications including cardiovascular and infectious diseases. Recent reports have demonstrated that gut microbiome disturbance is associated with both the etiology and progression of chronic kidney disease. However, the relationship between dietary phosphate and gut microbiome remains unknown. Here, we examined the effects of excessive intake of phosphate on gut microbiome. Five-week-old male C57BL/6J mice were fed either control diet or high phosphate diet for eight weeks. Analysis of the gut microbiota was carried out using MiSeq next generation sequencer, and short-chain fatty acids were determined with GC-‍MS. In analysis of gut microbiota, significantly increased in Erysipelotrichaceae and decreased in Ruminococcaceae were observed in high phosphate diet group. Furthermore, high phosphate diet induced reduction of microbial diversity and decreased mRNA levels of colonic tight junction markers. These results suggest that the excessive intake of dietary phosphate disturbs gut microbiota and affects intestinal barrier function.
掲載誌名
Journal of Clinical Biochemistry and Nutrition
ISSN
09120009
18805086
cat書誌ID
AA10710201
出版者
Society for Free Radical Research Japan
73
3
開始ページ
221
終了ページ
227
発行日
2023-11-01
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Naoko Odaの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/).
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3732号
学位記番号
甲栄第297号
学位授与年月日
2023-03-24
学位名
博士(栄養学)
学位授与機関
徳島大学
部局
医学系