| ID | 118573 |
| 著者 |
Takemori, Toshiyuki
Kobe University|Hyogo Cancer Center
Kawamoto, Teruya
Kobe University
Hara, Hitomi
Kobe University
Fukase, Naomasa
Kobe University
Fujiwara, Shuichi
Kobe University
Fujita, Ikuo
Hyogo Cancer Center
Fujimoto, Takuya
Hyogo Cancer Center
Morishita, Masayuki
Hyogo Cancer Center
Kitayama, Kazumichi
Kobe University
Yahiro, Shunsuke
Kobe University
Miyamoto, Tomohiro
Kobe University
Saito, Masanori
Japanese Foundation for Cancer Research
Sugaya, Jun
National Cancer Center Hospital
Hayashi, Katsuhiro
Kanazawa University
Kawashima, Hiroyuki
Niigata University
Torigoe, Tomoaki
Saitama Medical University
Nakamura, Tomoki
Mie University
Kondo, Hiroya
Okayama University
Wakamatsu, Toru
Osaka International Cancer Institute
Watanuki, Munenori
Tohoku University
Kito, Munehisa
Shinshu University
Tsukushi, Satoshi
Aichi Cancer Center Hospital
Nagano, Akihito
Gifu University
Outani, Hidetatsu
Osaka University
Nishimura, Shunji
Kindai University
Kobayashi, Hiroshi
The University of Tokyo
Watanabe, Itsuo
Tokyo Dental College
Demizu, Yusuke
Hyogo Ion Beam Medical Center Kobe Proton Center
Sasaki, Ryohei
Kobe University
Fukumoto, Takumi
Kobe University
Niikura, Takahiro
Kobe University
Kuroda, Ryosuke
Kobe University
Akisue, Toshihiro
Kobe University
|
| キーワード | pelvis
retroperitoneum
bone and soft tissue sarcoma
prognosis
prognostic factors
|
| 資料タイプ |
学術雑誌論文
|
| 抄録 | We aimed to clarify the clinical outcomes of patients with pelvic and retroperitoneal bone and soft tissue sarcoma. The 3-year overall survival (OS), local control (LC) rate, and progression-free survival (PFS) were 71.7%, 79.1%, and 48.6%, respectively. The most influential poor prognostic factor for OS was distant metastasis, and for PFS, this was higher age (≥60 years). Larger primary tumor size (≥10 cm) was the only poor prognostic factor for LC. In the histological analysis, osteosarcoma showed significantly worse OS and PFS than other sarcomas in the pelvis and retroperitoneum.
|
| 抄録別表記 | This study aimed to retrospectively analyze the clinical outcomes of patients with pelvic and retroperitoneal bone and soft tissue sarcoma (BSTS). Overall, 187 patients with BSTS in the pelvis and retroperitoneal region treated at 19 specialized sarcoma centers in Japan were included. The prognostic factors related to overall survival (OS), local control (LC), and progression-free survival (PFS) were evaluated. The 3-year OS and LC rates in the 187 patients were 71.7% and 79.1%, respectively. The 3-year PFS in 166 patients without any distant metastases at the time of primary tumor diagnosis was 48.6%. Osteosarcoma showed significantly worse OS and PFS than other sarcomas of the pelvis and retroperitoneum. In the univariate analyses, larger primary tumor size, soft tissue tumor, distant metastasis at the time of primary tumor diagnosis, P2 location, chemotherapy, and osteosarcoma were poor prognostic factors correlated with OS. Larger primary tumor size, higher age, soft tissue tumor, chemotherapy, and osteosarcoma were poor prognostic factors correlated with PFS in patients without any metastasis at the initial presentation. Larger primary tumor size was the only poor prognostic factor correlation with LC. This study has clarified the epidemiology and prognosis of patients with pelvic and retroperitoneal BSTS in Japan.
|
| 掲載誌名 |
Cancers
|
| ISSN | 20726694
|
| 出版者 | MDPI
|
| 巻 | 14
|
| 号 | 12
|
| 開始ページ | 3023
|
| 発行日 | 2022-06-20
|
| 権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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| EDB ID | |
| 出版社版DOI | |
| 出版社版URL | |
| フルテキストファイル | |
| 言語 |
eng
|
| 著者版フラグ |
出版社版
|
| 部局 |
医学系
|
