ID | 118874 |
著者 |
Hakoi, Haruka
Tokushima University
Nomura, Saki
Tokushima University
Murakami, Makoto
The University of Tokyo
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キーワード | contact hypersensitivity
dendritic cell
epidermis
gut microbiota
hair follicle
keratinocyte
lipid metabolism
phospholipase A2
psoriasis
skin
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資料タイプ |
学術雑誌論文
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抄録 | Among the phospholipase A2 (PLA2) family, the secreted PLA2 (sPLA2) family in mammals contains 11 members that exhibit unique tissue or cellular distributions and enzymatic properties. Current studies using knockout and/or transgenic mice for a nearly full set of sPLA2s, in combination with comprehensive lipidomics, have revealed the diverse pathophysiological roles of sPLA2s in various biological events. Individual sPLA2s exert specific functions within tissue microenvironments, likely through the hydrolysis of extracellular phospholipids. Lipids are an essential biological component for skin homeostasis, and disturbance of lipid metabolism by deletion or overexpression of lipid-metabolizing enzymes or lipid-sensing receptors often leads to skin abnormalities that are easily visible on the outside. Over the past decades, our studies using knockout and transgenic mice for various sPLA2s have uncovered several new aspects of these enzymes as modulators of skin homeostasis and disease. This article summarizes the roles of several sPLA2s in skin pathophysiology, providing additional insight into the research fields of sPLA2s, lipids, and skin biology.
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掲載誌名 |
Biomolecules
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ISSN | 2218273X
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出版者 | MDPI
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巻 | 13
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号 | 4
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開始ページ | 668
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発行日 | 2023-04-12
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権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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言語 |
eng
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著者版フラグ |
出版社版
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部局 |
生物資源系
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