ID | 119067 |
著者 | |
キーワード | Imeglimin (Twymeeg)
Oral hypoglycemic agent (OHA)
Trials of IMeglimin for Efficacy and Safety (TIMES)
Mitochondrial morphology
Lactic acidosis
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資料タイプ |
学術雑誌論文
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抄録 | A novel imeglimin (Twymeeg) was developed as an oral hypoglycemic agent (OHA) in Japan. It has clinically dual action for increasing insulin secretion and reducing insulin resistance, from Trials of IMeglimin for Efficacy and Safety (TIMES) 1-3. For basic medicine, imeglimin revealed reduction of apoptotic β-cell death with reduced expression for inflammation. Thus, imeglimin may increase insulin granules, bring beneficial efficacy on β-cell mitochondrial morphology and enhance directly insulin secretion from β-cell of the pancreas. Imeglimin has chemical moiety for metformin. Compared with both agents using experiments of dog and mice, lactic acidosis would be lower in imeglimin group.
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掲載誌名 |
SunText Review of Case Reports & Images
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ISSN | 27664589
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出版者 | SunText Reviews
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巻 | 3
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号 | 4
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開始ページ | 158
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発行日 | 2022-10-27
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権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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出版社版DOI | |
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フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
医学系
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