遺伝性乳がん卵巣がん症候群に対するリスク低減卵巣卵管摘出術への意思決定に関する海外の動向

Hereditary breast and ovarian cancer syndrome（HBOC） has been reported to account for about 10-15％ of all ovarian cancers, and risk-reducing salpingo-oophorectomy（RRSO） is regarded as the only preventive measure against the risk of such cancers. It is important for patients with BRCA 1/2 pathogenic variants to undergo RRSO after childbearing, between the ages of 35 to 45, but a multifaceted perspective is needed when considering this procedure, as it may cause physical and psychological problems. This paper discusses factors that influence decision-making regarding RRSO from three perspectives : demographics, medical history, and psychosociology, with reference to previous studies. Accurate insight into the background that led to the decision to undergo RRSO is crucial for support. Above all, it is essential to utilize such insight in healthcare as vital information to prevent death from breast or ovarian cancer among HBOC patients.